NEW YORK (CNN) -- Actress Jennifer Aniston says her latest film, "Derailed," is a departure from the funny, girl-next-door roles that helped make her famous.In an interview on CNN's "Larry King Live," the former "Friends" star was tight-lipped about her personal life -- including her very public divorce from Brad Pitt and her rumored relationship with "Wedding Crashers" star Vince Vaughn.Aniston laughed but refused to answer when asked about Vaughn and instead repeated King when he said "we love him," and "he's a national treasure." (Watch Jennifer Aniston on public breakup: 'It's a bitch" -- 1:25)When asked why, she replied "because it's none of your -- I don't mean to say that. It sounds harsh to say 'it's none of your business' but it's -- I've learned my -- you know you learn your lessons. That's all."Aniston said she met Vaughn when they were working together on the romantic comedy "The Break Up," which is scheduled for release next year.Much to the tabloids' delight, Vaughn had also appeared in "Mr. & Mrs. Smith," with Pitt and Angelina Jolie, who were said to be romantically involved in the months leading up to Aniston's divorce from Pitt. (Full story)Aniston said she stays away from the tabloids."It's toxic ... I want no part of it and it's the only way you can really go through, walk through anything like that with any kind of dignity is to just not succumb to that crap," she said.She said that the paparazzi frequently cross the line and invade her privacy because "they just want a photograph so they can make a buck.""I'm on the clock. We're on the clock, we're working right now. I think when you're off the clock, you should be off the clock," she said. "You don't follow them to their private events and to their children's schools and to their family or friends' funerals or whatever. I mean, it's just -- come on, it's common sense."Aniston said she signed on for "Derailed," which opens Friday, because the thriller "was just a different part than usually comes my way."She and co-star Clive Owen play married executives who meet on the train ride to work and have a one-night stand.That affair goes about as wrong as humanly possible, when a man bursts into their hotel room and goes on to terrorize them and their families."I just feel lucky to be able to do things other than that character, you know, other than Rachel (her "Friends" character) to be able to sort of move on into films and be accepted," she said."Friends," which catapulted her to fame, stays on her mind. She's best friends with "Friends" castmate Courteney Cox and the six main actors always negotiated contracts together -- which led to huge paydays late in the show's run."I miss them, that's the one thing I miss terribly -- the crew, the writers. Everybody worked there together so long, everyday, eight months out of the year," she told The Associated Press. "Like school ... depending on what kind of a student you were."Owen, best known for his dark hero roles in "Sin City" and "King Arthur," said Aniston was "a brilliant choice" and was fantastic to work with in "Derailed." "I was a big fan of the script. I felt the character was unusual and that he was completely reactive the whole film. It's like he's not -- he's not the guy that drives the story," he said. "The story attacks him and there was just something very attractive about playing that."